FASCINATION ABOUT CONOLIDINE ALKALOID FOR CHRONIC PAIN

When the opiate receptor depends on G protein coupling for signal transduction, this receptor was located to employ arrestin activation for internalization in the receptor. Normally, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. This binding in the long

Scientists have a short while ago determined and succeeded in synthesizing conolidine, a organic compound that displays assure like a strong analgesic agent with a more favorable safety profile. Although the correct system of action remains elusive, it is actually at the moment postulated that conolidine could possibly have several biologic targets